New Study Shows MRSA Tricks Immune System

By Alice Turner
21:37, November 12th 2007
117 votes
Vote this story
New Study Shows MRSA Tricks Immune System

A new study shows that Methicillin-resistant Staphylococcus aureus (MRSA) may trick and destroy immune system cells when they are vulnerable. The research, published in the journal Nature Medicine, found that some strains on MRSA secrete a compound called phenol-soluble modulin (PSM). This substance attracts immune system cells called neutrophils and then destroys them in a process called lysis.

"This elegant work helps reveal the complex strategy that S. aureus has developed to evade our normal immune defenses," Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said in a statement.

"Understanding what makes the infections caused by these new strains so severe and developing new drugs to treat them are urgent public health priorities."

There are two main types of MRSA. The hospital-acquired MRSA, which is responsible for nosocomial infections, is much more dangerous because it is resistant to most antibiotics. The community-acquired MRSA usually is caused in the United States by a strain designated ST8:USA300. This type of infection is more virulent but a lot easier to treat, and in many cases antibiotics are not required.

"Here we describe a class of secreted staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection," the researchers wrote.

Paranoia was unleashed after this October researchers reported that MRSA was responsible for 94,000 hospitalizations and may have contributed to 19,000 deaths in 2005 in the United States. These figures were distorted by the media and interpreted as if the 19,000 deaths were caused by the MRSA, which is false. MRSA was found in 19,000 people who died, but the vast majority of those had other primary, lethal diseases.

There are antibiotics which kill of most nosocomial MRSA infections, but they are used only as a last resort as otherwise resistant strains would pop up everywhere. In fact, a MRSA dubbed vancomycin intermediate-resistant Staphylococcus aureus (VISA) has appeared, which is resistant to the powerful vancomycin antibiotic. In 2006, Merck reported in Nature that they discovered an entirely new type of antibiotic, called platensimycin, which is allegedly very successful against MRSA.



© 2007 - 2009 - eFluxMedia
dotclear

Other News in

Gene Predicts the Likelihood of ALL Recurrence

Gene Predicts the Likelihood of ALL Recurrence

  Acute lymphoblastic leukemia or ALL is the most common type of cancer in children affecting about one in 30,000 each year. Current drugs for the disease have put the cure rates close to 80...

Teens Tackle Risky Behaviour on MySpace

Teens Tackle Risky Behaviour on MySpace

Many teens and college students enjoy talking about sex, drugs and violence on MySpace or Facebook, a new study shows. But they are disposed to change their risky behaviour if they are given the...

Salmonella Outbreak Continues to Spread in More States

Salmonella Outbreak Continues to Spread in More States

Ohio health officials have announced at least 50 people in 18 countries have been sickened by salmonella bacteria in the most recent salmonella outbreak. The last case reported in Ohio was Dec. 12....

FDA: New Drug from Genetically Engineered Goats May Be on Its Way

FDA: New Drug from Genetically Engineered Goats May Be on Its Way

The Food and Drug Administration revealed Wednesday that for the first time an anti-clotting drug made from the milk of genetically engineered goats works and its safety is acceptable.   The...

FDA Refuses To Approve Lilly’s Long-Acting Zyprexa

FDA Refuses To Approve Lilly’s Long-Acting Zyprexa

  The US Food and Drug Administration refused to immediately approve a long-acting formulation of schizophrenia drug Zyprexa requesting its maker details regarding its risks.   Eli Lilly...

dotclear
Latest videos in Health
Plastic Bags Help to Save...
Nuclear knuckles
Restoring the pee-h balance
Bird flu alert in Hong Kong
Ireland in pork product alert

dotclear
Health You are here: Health
» Science   » Health   
E-mail To A Friend Print RSS Text size: Decrease font size Increase font size
dotclear
dotclear
dotclear
Most Popular in Health
UAMS Scientists To Begin Testing Breast Cancer VaccineUAMS Scientists To Begin Testing Breast Cancer Vaccine

» read full story
dotclear

Interested In This Topic?

News Alert will keep you informed. Find out more.
dotclear
Photos Gallery
dotclear
Today's Latest News
Obama’s Health Care System Reform Plans Draw Mixed ReactionObama’s Health Care System Reform Plans Draw Mixed Reaction

» read full story
dotclear